Non-profit organisations (NPOs) have become essential change agents in a world where youth unemployment is on the rise and meaningful and sustainable employment is desperately needed, particularly in Ghana, where youth unemployment remains one of the highest in Africa. As a result, the purpose of this literature review is to provide insights into the role of NPOs in creating dignified and fulfilling jobs for the youth in Ghana. To achieve this, a thorough analysis of the literature was conducted to identify the contributions of the non-profit sector in creating jobs for the youth. The search period spans from 1992 to 2023. Additionally, content analysis of international organisations, NPOs, and government reports were examined to provide further insight into the role of NPOs in job creation for the youth. In so doing, the review identifies the gaps in existing literature, which provides a basis for future research. The literature suggests that NPOs have played a major role in empowering youth in Ghana through entrepreneurial, vocational, educational, agricultural and skill-development initiatives. These programmes provide job opportunities for the youth and also give them the skills and information needed to acquire dignified and fulfilling jobs. In addition, NPOs in Ghana collaborate with international development partners, local philanthropies, and government agencies to secure funding and support to implement youth-focused employment programmes. Despite these efforts, the review of existing literature shows that the impact of NPOs in creating dignified jobs for the youth has yet to be substantially recognised. This literature review provides insights into pockets of opportunities for the non-profit sector to create dignified and fulfilling jobs for the youth in Ghana. Also, it identifies emerging knowledge gaps in the literature that should be the focus of future research.