This literature review explores the contributions of the non-profit sector (NPOs) to economic development and the creation of dignified and fulfilling work for young people in Senegal. With youth unemployment remaining a critical challenge—especially among women and rural populations the study examines how Senegal’s dense and heterogeneous NPO ecosystem can address this issue. The research draws on a comprehensive review of literature and interviews, classifying NPOs into five categories: NGOs, foundations, associations, cooperatives, and economic interest groups. Although data on economic impact remain limited, NPOs play a vital role in promoting vocational training, entrepreneurship, and social inclusion. The review also highlights the importance of formalising the informal sector, harnessing digital transformation, and strengthening policy advocacy. It identifies key gaps in data and institutional capacity and proposes strategies for increasing the sector’s impact on job creation, particularly for marginalized youth. Ultimately, the paper underscores the potential of NPOs as crucial actors in shaping Senegal’s youth employment landscape, while calling for improved measurement frameworks and cross-sector collaboration.