The non-profit sector plays a significant role in economic development and social transformation in Rwanda, particularly in addressing youth unemployment. However, the extent of its contribution to empowering African economies, especially Rwanda, remains underexplored. This desk review examines how non-profit organisations support the Rwandan economy by creating dignified and fulfilling employment opportunities for young people. The analysis highlights the various mechanisms through which non-profits facilitate youth employment, including vocational training, entrepreneurship support, and labour market advocacy. The study synthesises findings from policy documents, scholarly literature, and national reports to assess the sector’s role in job creation, skills development, and youth empowerment. Existing research suggests that non-profits contribute significantly by equipping young people with technical and entrepreneurial skills, supporting small business development, and advocating for inclusive labour policies. However, despite these contributions, challenges persist in terms of financial sustainability, alignment with national employment policies, and labour market integration. Findings indicate that non-profits are key actors in bridging gaps in formal employment by offering alternative pathways for youth to gain economic stability. The review also identifies knowledge gaps, particularly in quantifying the sector’s impact on broader employment trends. While success stories demonstrate effective models of intervention, further policy engagement is required to ensure long-term sustainability and scalability. This analysis underscores the strategic importance of strengthening the non-profit sector to address youth unemployment and promote economic inclusivity in Rwanda. By reinforcing collaboration between non-profits, government institutions, and private sector actors, policymakers can enhance the sector’s capacity to generate employment and foster long-term economic resilience.