Youth unemployment is a significant challenge in Uganda, particularly among marginalised youth. While formal employment remains limited, many young people turn to the informal sector for livelihoods. This literature review explores the contributions of non-profit organisations (NPOs)—commonly referred to as NGOs in Uganda—to the creation of dignified and fulfilling work for youth. The study employs a comprehensive desktop review of existing literature, including academic articles, government and NGO reports, and news sources, to assess the economic role of NPOs in youth employment. It finds that NPOs contribute both directly—through job creation within their organisations—and indirectly, by supporting youth-focused initiatives such as incubators, training programmes, and access to microcredit. Despite their contributions, the review highlights a significant data gap regarding the quantity, quality, and sustainability of jobs created by the non-profit sector. It recommends using mixed-methods research and the ILO’s decent work framework to better assess the impact of NPOs on youth employment in Uganda. The review also identifies agriculture, services, and digital technology as key areas for intervention and scaling dignified work opportunities.